Some USB 3 devices don't particularly like being plugged in USB 2 and some USB 2 devices don't like USB 3.

Also, search for USB/Chipset driver updates. Maybe uninstall the USB drivers and reinstall. If that doesn't fix the issue, it was in Safe Mode, so no joke/malicious programs should be running. Swap back to the original mouse and see if the problem comes back. If no problem then the keyboard was contributing. If the problem still persists, swap out the keyboard with a new one (different brand/model if possible) and repeat #1 and #2.If no problem, then the mouse was contributing and you can start trying to put things back the way it was one thing at a time and see if the problem comes back. If the problem still persists, in Safe Mode swap out the mouse with a new one (different brand/model if possible) and repeat #1 and #2.If the problem persists, in Safe Mode try plugging them into a different hub on the computer, if available, so if they were in the back then try them in the front.In Safe Mode, I would unplug all but the keyboard and mouse, plug those two directly into the computer to see what the results are.Not saying that's the case, but something to consider. I've encountered some early USB 3 ports on some motherboards that had software and drivers that installed and there was software that ran on startup.

Have you tried Safe Mode to rule out any joke/malicious programs?.Do you have another one around that you can swap it out with to see if there is a problem with the hub itself?.Is the user trying to charge any phone or other devices through this hub?.Are there any USB 3 devices plugged into it?.What brand/model is the powered USB hub?.

Windows 10 device disconnect sound